MAP3K8

Across TCGA pan-cancer cohorts, MAP3K8 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of MAP3K8’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where MAP3K8 RNA is repressed in tumor relative to normal tissue. In most cancer types MAP3K8 is over-expressed in tumor, although a few such as BLCA and LUAD show the opposite, repressed pattern.

BLCA, LUAD, and THCA are the cancer types where MAP3K8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MAP3K8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	III,IV	−1.492	<.001	11	view →
LUAD	Male	II,III,IV	−1.507	<.001	8	view →
THCA	Male	All	−1.100	<.001	8	view →
HNSC	Male	II,III,IV	−0.943	<.001	8	view →
COAD	All	II,III,IV	+0.650	<.001	8	view →
KICH	All	All	−0.792	<.001	7	view →
LUSC	Male	II,III,IV	−1.673	<.001	6	view →
BRCA	All	III,IV	−1.555	<.001	6	view →
UCEC	All	All	−1.118	<.001	6	view →
KIRC	Male	All	+0.409	.001	4	view →
CHOL	All	All	+1.565	<.001	3	view →
PAAD	All	All	−1.170	.033	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

MAP3K8–BLCA

Open the BLCA breakdown →