MAP3K8

Across TCGA pan-cancer cohorts, MAP3K8 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated MAP3K8 data layer compared with 3 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher MAP3K8 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MAP3K8 expression acts as an unfavorable survival marker, although some lineages such as MESO and SKCM show a favorable association.

KIRC, MESO, and SKCM are the cancer types where MAP3K8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	All	0.491	0.723	<.001	99	view →
MESO	DFS	Quartile	All	0.533	0.261	.002	71	view →
SKCM	OS	Median	All	0.415	0.259	<.001	66	view →
UVM	DFS	Median	III,IV	0.264	0.799	.001	54	view →
THCA	OS	Quartile	II,III,IV	0.935	1.000	.005	28	view →
LUAD	DFS	Quartile	III,IV	0.671	0.265	.013	27	view →
LGG	DFS	Median	All	0.335	0.448	.002	25	view →
COAD	DFS	Median	IV	0.373	0.612	.010	21	view →
BLCA	OS	Tertile	All	0.672	0.544	.027	21	view →
ACC	OS	Quartile	All	0.687	1.000	.008	19	view →
SARC	OS	Quartile	All	0.903	0.712	<.001	18	view →
GBM	DFS	Quartile	All	0.164	0.475	.001	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

MAP3K8–KIRC (DFS)

Open the KIRC breakdown →