MAK

Across TCGA cell cohorts, MAK mutation is significantly associated with the RNA expression of many other genes, with 166 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAK-associated genes across cancer lineages are PLA2G3, EIF3L, and LIPG. Each is linked with MAK in more than 1 cancer types. Because this analysis shows association rather than direction, both MAK-to-partner and partner-to-MAK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PLA2G3 grouped by MAK-low versus MAK-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAK→partner) and Y-score (partner→MAK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PLA2G3 →	+1.150	+3.082	<.001	.007	3	1
LARGE_INTESTINE	EIF3L →	+0.440	+3.237	.009	.003	3	1
LARGE_INTESTINE	LIPG →	+1.692	+3.459	<.001	.001	3	1
LARGE_INTESTINE	NDUFC1 →	+0.566	+2.502	.005	.005	3	1
LARGE_INTESTINE	ATP5F1B →	+0.480	+2.502	.002	.005	3	1
LARGE_INTESTINE	SMC4 →	-0.665	-3.541	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 166 associations by consensus.

PLA2G3 by MAK expression — LARGE_INTESTINE

Explore this box plot interactively →