MAK

Across TCGA pan-cancer cohorts, MAK RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of MAK’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where MAK RNA is repressed in tumor relative to normal tissue. In most cancer types MAK is over-expressed in tumor, although a few such as LUSC and THCA show the opposite, repressed pattern.

LUSC, THCA, and LUAD are the cancer types where MAK tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MAK RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	All	II,III,IV	−1.308	<.001	9	view →
THCA	Female	All	−0.609	<.001	9	view →
LUAD	All	All	−0.569	.003	6	view →
STAD	All	II,III,IV	+0.481	.004	6	view →
COAD	All	II,III,IV	+0.199	<.001	6	view →
CHOL	All	All	+0.878	<.001	5	view →
KIRC	All	III,IV	−0.134	.022	3	view →
BRCA	All	IV	−1.095	.032	2	view →
PRAD	All	All	+0.542	<.001	2	view →
KICH	All	All	−0.311	.012	2	view →
READ	All	All	+0.167	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

MAK–LUSC

Open the LUSC breakdown →