MAD2L1BP

Across TCGA patient cohorts, MAD2L1BP mutation is significantly associated with the RNA expression of many other genes, with 75 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAD2L1BP-associated genes across cancer lineages are SYPL1P1, RNU6-451P, and RNA5SP405. Each is linked with MAD2L1BP in more than 1 cancer types. Because this analysis shows association rather than direction, both MAD2L1BP-to-partner and partner-to-MAD2L1BP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SYPL1P1 grouped by MAD2L1BP-low versus MAD2L1BP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAD2L1BP→partner) and Y-score (partner→MAD2L1BP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SYPL1P1 →	+0.264	+4.216	<.001	<.001	3	2
UCEC	RNU6-451P →	+0.905	+3.386	<.001	.008	3	1
UCEC	RNA5SP405 →	+0.509	+4.260	<.001	.007	3	1
UCEC	RNU6-1169P →	+0.363	+3.302	.001	.009	3	1
UCEC	RNU6-1020P →	+0.517	+4.005	<.001	.002	3	1
UCEC	RNU6-1318P →	+0.678	+3.943	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 75 associations by consensus.

SYPL1P1 by MAD2L1BP expression — UCEC

Explore this box plot interactively →