MAD2L1BP

Across TCGA pan-cancer cohorts, MAD2L1BP RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated MAD2L1BP data layer compared with 3 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher MAD2L1BP RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MAD2L1BP expression acts as an unfavorable survival marker, although some lineages such as KIRC and MESO show a favorable association.

UVM, KIRC, and ACC are the cancer types where MAD2L1BP RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Quartile	II,III,IV	0.332	0.760	<.001	76	view →
KIRC	DFS	Quartile	All	0.847	0.725	<.001	56	view →
ACC	DFS	Tertile	All	0.189	0.706	<.001	48	view →
LIHC	DFS	Median	All	0.474	0.606	.002	45	view →
MESO	OS	Quartile	II,III,IV	0.481	0.235	.003	44	view →
KICH	OS	Quartile	II,III,IV	0.444	1.000	.001	41	view →
LUSC	OS	Quartile	All	0.486	0.318	.003	19	view →
OV	DFS	Median	IV	0.392	0.230	.018	16	view →
THYM	OS	Tertile	All	1.000	0.759	.007	14	view →
STAD	DFS	Median	II,III,IV	0.466	0.201	.005	12	view →
ESCA	OS	Tertile	IV	0.393	0.743	.024	12	view →
READ	OS	Median	IV	0.504	0.932	.006	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

MAD2L1BP–UVM (DFS)

Open the UVM breakdown →