MACROH2A1

Across TCGA patient cohorts, MACROH2A1 mutation is significantly associated with the RNA expression of many other genes, with 1,397 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MACROH2A1-associated genes across cancer lineages are EDDM3DP, MTCO1P57, and FAM177A1P1. Each is linked with MACROH2A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MACROH2A1-to-partner and partner-to-MACROH2A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EDDM3DP grouped by MACROH2A1-low versus MACROH2A1-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MACROH2A1→partner) and Y-score (partner→MACROH2A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	EDDM3DP →	+0.100	+6.479	<.001	.001	3	2
BRCA	MTCO1P57 →	+0.177	+5.646	<.001	.004	3	2
UCEC	FAM177A1P1 →	+0.120	+2.113	<.001	<.001	3	2
LIHC	TRAJ37 →	+0.580	+5.355	<.001	.005	3	1
LIHC	KCNIP4-IT1 →	+0.009	+5.033	<.001	.009	3	1
UCEC	CCL5 →	+0.927	+2.223	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,397 associations by consensus.

EDDM3DP by MACROH2A1 expression — LIHC

Explore this box plot interactively →