MACROH2A1

Across TCGA pan-cancer cohorts, MACROH2A1 RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of MACROH2A1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MACROH2A1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MACROH2A1 is over-expressed in tumor.

KIRC, BLCA, and COAD are the cancer types where MACROH2A1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MACROH2A1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	IV	+0.465	<.001	12	view →
BLCA	Male	III,IV	+1.234	<.001	11	view →
COAD	Female	II,III,IV	+0.672	<.001	11	view →
LIHC	Female	II,III,IV	+1.292	<.001	9	view →
STAD	All	III,IV	+0.930	<.001	9	view →
THCA	Female	III,IV	+0.484	<.001	9	view →
KIRP	All	II,III,IV	+0.544	<.001	8	view →
LUAD	Female	All	+0.329	<.001	7	view →
UCEC	All	III,IV	+1.267	<.001	6	view →
BRCA	All	III,IV	+1.259	<.001	6	view →
CHOL	Female	All	+2.770	<.001	5	view →
LUSC	All	All	+0.342	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

MACROH2A1–KIRC

Open the KIRC breakdown →