LY6H

Across TCGA patient cohorts, LY6H mutation is significantly associated with the RNA expression of many other genes, with 130 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible LY6H-associated genes across cancer lineages are IGKV2D-23, RAB28P2, and ANKRD62P1-PARP4P3. Each is linked with LY6H in more than 1 cancer types. Because this analysis shows association rather than direction, both LY6H-to-partner and partner-to-LY6H results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGKV2D-23 grouped by LY6H-low versus LY6H-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LY6H→partner) and Y-score (partner→LY6H) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	IGKV2D-23 →	+0.224	+5.812	<.001	.003	3	2
SKCM	RAB28P2 →	+0.040	+4.302	.002	.007	3	2
SKCM	ANKRD62P1-PARP4P3 →	+0.162	+3.126	.003	.007	3	2
BLCA	FTH1P9 →	+0.104	+7.640	<.001	.009	3	2
SKCM	TEX28 →	+0.019	+4.147	<.001	.008	3	2
SKCM	CKS1BP5 →	+0.082	+4.475	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 130 associations by consensus.

IGKV2D-23 by LY6H expression — CESC

Explore this box plot interactively →