LY6H

Across TCGA pan-cancer cohorts, LY6H RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated LY6H data layer compared with 1 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher LY6H RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated LY6H expression acts as an unfavorable survival marker, although some lineages such as LGG and THYM show a favorable association.

KIRP, LUSC, and LIHC are the cancer types where LY6H RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	IV	0.039	0.593	.008	46	view →
LUSC	DFS	Quartile	II,III,IV	0.229	0.547	<.001	46	view →
LIHC	DFS	Median	All	0.455	0.629	<.001	46	view →
LUAD	DFS	Tertile	IV	0.262	0.829	.006	45	view →
UCS	DFS	Median	IV	0.367	0.952	.001	42	view →
OV	DFS	Tertile	II,III,IV	0.112	0.194	.006	34	view →
LGG	OS	Quartile	All	0.580	0.406	.002	26	view →
UVM	OS	Median	III,IV	0.296	1.000	.005	26	view →
SARC	OS	Median	All	0.353	0.624	.001	21	view →
UCEC	OS	Quartile	All	0.834	0.933	.007	20	view →
THYM	OS	Median	All	1.000	0.920	.010	20	view →
PAAD	OS	Quartile	All	0.710	0.231	.005	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

LY6H–KIRP (DFS)

Open the KIRP breakdown →