LY6E

Across TCGA patient cohorts, LY6E mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LY6E-associated genes across cancer lineages are DEFB109C, RNU2-47P, and OR5M8. Each is linked with LY6E in more than 1 cancer types. Because this analysis shows association rather than direction, both LY6E-to-partner and partner-to-LY6E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB109C grouped by LY6E-low versus LY6E-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LY6E→partner) and Y-score (partner→LY6E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	DEFB109C →	+0.119	+7.924	<.001	.008	3	1
LUSC	RNU2-47P →	+0.412	+7.924	<.001	.008	3	1
UCEC	OR5M8 →	+0.118	+6.335	.009	.001	3	1
UCEC	RNU1-34P →	+0.550	+6.226	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

DEFB109C by LY6E expression — LUSC

Explore this box plot interactively →