LTF

Across TCGA patient cohorts, LTF mutation is significantly associated with the RNA expression of many other genes, with 3,535 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LTF-associated genes across cancer lineages are RDM1P1, RNU6-552P, and RNU6-41P. Each is linked with LTF in more than 2 cancer types. Because this analysis shows association rather than direction, both LTF-to-partner and partner-to-LTF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RDM1P1 grouped by LTF-low versus LTF-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LTF→partner) and Y-score (partner→LTF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RDM1P1 →	+0.067	+6.051	<.001	<.001	3	3
BRCA	RNU6-552P →	+0.297	+5.259	<.001	.007	3	3
BLCA	RNU6-41P →	+0.142	+4.289	.001	.007	3	3
SKCM	TMPPE →	+0.362	+2.019	.001	.005	3	3
UCEC	UQCR10 →	+0.285	+1.970	<.001	<.001	3	3
UCEC	TPM3P9 →	+0.486	+1.516	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,535 associations by consensus.

RDM1P1 by LTF expression — BLCA

Explore this box plot interactively →