LTF

Across TCGA pan-cancer cohorts, LTF RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of LTF’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where LTF RNA is repressed in tumor relative to normal tissue. In most cancer types LTF is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

THCA, KIRC, and HNSC are the cancer types where LTF tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LTF RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−3.675	<.001	11	view →
KIRC	All	IV	−3.090	<.001	11	view →
HNSC	Male	II,III,IV	−5.352	<.001	10	view →
KICH	All	All	−2.067	<.001	8	view →
BRCA	Female	All	−1.924	<.001	6	view →
BLCA	All	III,IV	−1.638	.014	4	view →
LUAD	Female	All	+1.519	<.001	4	view →
KIRP	All	III,IV	−2.084	.041	2	view →
PRAD	All	All	−1.312	.026	2	view →
COAD	Female	III,IV	−1.124	.010	2	view →
STAD	All	IV	−5.116	.002	1	view →
LUSC	Female	III,IV	+4.430	.011	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

LTF–THCA

Open the THCA breakdown →