LTF

Across TCGA pan-cancer cohorts, LTF RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated LTF data layer compared with 4 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in brain lower grade glioma (LGG), where higher LTF RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated LTF expression acts as an unfavorable survival marker, although some lineages such as HNSC and KIRC show a favorable association.

LGG, UVM, and HNSC are the cancer types where LTF RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	DFS	Median	All	0.661	0.814	<.001	53	view →
UVM	DFS	Tertile	All	0.430	0.750	.001	48	view →
HNSC	DFS	Median	III,IV	0.457	0.192	<.001	48	view →
STAD	OS	Median	All	0.457	0.645	.001	47	view →
KIRC	DFS	Quartile	All	0.841	0.707	.001	44	view →
SARC	DFS	Median	All	0.705	0.516	<.001	41	view →
UCS	OS	Tertile	IV	0.844	0.228	.024	30	view →
BLCA	DFS	Tertile	IV	0.111	0.404	.014	22	view →
CHOL	DFS	Median	All	0.650	0.202	.012	18	view →
THCA	OS	Median	All	0.962	1.000	.010	15	view →
SKCM	DFS	Median	II,III,IV	0.309	0.202	.010	14	view →
LUSC	DFS	Quartile	All	0.339	0.471	.022	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

LTF–LGG (DFS)

Open the LGG breakdown →