LSM10

Across TCGA patient cohorts, LSM10 mutation is significantly associated with the RNA expression of many other genes, with 54 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible LSM10-associated genes across cancer lineages are SPCS2P2, COX6B1P1, and OR52X1P. Each is linked with LSM10 in more than 1 cancer types. Because this analysis shows association rather than direction, both LSM10-to-partner and partner-to-LSM10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPCS2P2 grouped by LSM10-low versus LSM10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LSM10→partner) and Y-score (partner→LSM10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SPCS2P2 →	+0.162	+4.520	<.001	.001	3	1
SKCM	COX6B1P1 →	+0.358	+3.880	<.001	.004	3	1
SKCM	OR52X1P →	+0.083	+4.097	<.001	.002	3	1
SKCM	OR51B8P →	+0.141	+4.292	<.001	.001	3	1
SKCM	RNA5SP57 →	+0.259	+4.328	<.001	.007	3	1
SKCM	RN7SL251P →	+0.133	+4.292	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

SPCS2P2 by LSM10 expression — UCEC

Explore this box plot interactively →