LSM10

Across TCGA pan-cancer cohorts, LSM10 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of LSM10’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where LSM10 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LSM10 is over-expressed in tumor, although a few such as KICH and PRAD show the opposite, repressed pattern.

HNSC, LIHC, and KICH are the cancer types where LSM10 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LSM10 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.601	<.001	12	view →
LIHC	Male	II,III,IV	+0.956	<.001	9	view →
KICH	Female	II,III,IV	−1.485	<.001	8	view →
COAD	Female	All	+0.757	<.001	6	view →
UCEC	All	All	+0.348	.008	6	view →
BRCA	Female	All	+0.275	<.001	6	view →
LUSC	All	All	+0.239	.001	5	view →
CHOL	Male	All	+1.423	<.001	4	view →
STAD	All	II,III,IV	+0.422	.016	3	view →
ESCA	All	All	+0.728	.002	2	view →
PRAD	All	All	−0.288	<.001	2	view →
THCA	Male	II,III,IV	−0.286	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

LSM10–HNSC

Open the HNSC breakdown →