LRRN4CL

Across TCGA patient cohorts, LRRN4CL protein abundance is significantly associated with the RNA expression of many other genes, with 3,026 significant associations in total. GBM shows the largest number of these associations.

The most reproducible LRRN4CL-associated genes across cancer lineages are TOPBP1, SMC4, and BRIP1. Each is linked with LRRN4CL in more than 3 cancer types. Because this analysis shows association rather than direction, both LRRN4CL-to-partner and partner-to-LRRN4CL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LRRN4CL versus TOPBP1 in OV, with a Pearson correlation of -0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRN4CL→partner) and Y-score (partner→LRRN4CL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TOPBP1 →	-0.645	-0.796	.003	<.001	3	4
LUAD	SMC4 →	-1.203	-0.405	<.001	<.001	3	3
OV	BRIP1 →	-1.114	-0.985	<.001	<.001	3	3
OV	MCM2 →	-1.193	-0.930	.003	<.001	3	3
LUAD	XPO5 →	-0.416	-0.300	.003	<.001	3	3
UCEC	C1orf109 →	-0.549	-0.381	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,026 associations by consensus.

LRRN4CL vs TOPBP1 — OV

Explore this scatter interactively →