LRRD1

Across TCGA cell cohorts, LRRD1 mutation is significantly associated with the mutation status of many other genes, with 2,324 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRRD1-associated genes across cancer lineages are ZNF676, PEAR1, and PRAMEF2. Each is linked with LRRD1 in more than 2 cancer types. Because this analysis shows association rather than direction, both LRRD1-to-partner and partner-to-LRRD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF676 grouped by LRRD1-low versus LRRD1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRD1→partner) and Y-score (partner→LRRD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ZNF676 →	+5.044	+5.614	.003	.003	1	3
SKIN	PEAR1 →	+4.824	+5.392	.004	.004	1	3
SKIN	PRAMEF2 →	+5.824	+5.824	.002	.002	1	3
BLOOD_Lymphoma	POLR1B →	+5.014	+5.584	.003	.003	1	3
BLOOD_Lymphoma	ARID2 →	+4.014	+4.969	.008	.008	1	3
LARGE_INTESTINE	NACA →	+2.422	+4.050	.004	.004	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,324 associations by consensus.

ZNF676 by LRRD1 expression — CNS

Explore this box plot interactively →