LRRD1

Across TCGA pan-cancer cohorts, LRRD1 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of LRRD1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where LRRD1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LRRD1 is over-expressed in tumor.

HNSC, KIRC, and CHOL are the cancer types where LRRD1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LRRD1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+0.034	<.001	8	view →
KIRC	Male	All	+0.012	.001	3	view →
CHOL	All	All	+0.044	.016	2	view →
KIRP	All	IV	+0.022	.031	2	view →
KICH	All	All	+0.022	.010	2	view →
STAD	All	IV	+0.020	.013	1	view →
LUSC	All	All	+0.017	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

LRRD1–HNSC

Open the HNSC breakdown →