LRRC43

Across TCGA patient cohorts, LRRC43 mutation is significantly associated with the RNA expression of many other genes, with 1,565 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC43-associated genes across cancer lineages are MIR548E, TIMM22, and RPS12P15. Each is linked with LRRC43 in more than 2 cancer types. Because this analysis shows association rather than direction, both LRRC43-to-partner and partner-to-LRRC43 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR548E grouped by LRRC43-low versus LRRC43-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC43→partner) and Y-score (partner→LRRC43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	MIR548E →	+0.278	+5.008	<.001	.004	3	3
UCEC	TIMM22 →	+0.396	+2.316	<.001	<.001	3	3
BLCA	RPS12P15 →	+0.169	+5.082	<.001	<.001	3	3
UCEC	RNU6-1213P →	+0.112	+2.761	<.001	.009	3	3
COAD	ZNHIT1P1 →	+0.265	+2.422	.004	.009	3	2
COAD	TRGJP2 →	+0.703	+2.489	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,565 associations by consensus.

MIR548E by LRRC43 expression — LIHC

Explore this box plot interactively →