Q-omics provides the consensus-scored MIR548E profile across patient tissues and cancer cell-line models. MIR548E expression is associated with patient survival in 13 of 34 cancer types, with the highest sampling consensus in HNSC. Among the 18 cancer types available for tumor–normal comparison, MIR548E is differentially expressed in 3, with the highest sampling consensus in THCA. Additionally, MIR548E RNA expression shows 10,088 significant gene co-expression associations, with the highest sampling consensus in COAD. Together, these results highlight HNSC, THCA, and COAD as cancer lineages where MIR548E shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MIR548E — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MIR548E survival associations across molecular data types. MIR548E RNA expression shows survival associations in the most cancer types (13). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MIR548E RNA expression–survival associations across cancer types. High MIR548E expression shows unfavorable associations in UCS, BLCA, DLBC, PCPG and KIRP, but favorable associations in HNSC. The HNSC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .006). Together, the overview and detailed table identify HNSC as the clearest survival context for MIR548E RNA expression.
This table summarizes MIR548E tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 3. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for MIR548E. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MIR548E shows lower tumor expression in THCA and COAD and higher tumor expression in KIRC. The THCA box plot shows higher MIR548E RNA expression in normal versus tumor tissue (log2 FC = −0.223, t-test p < 0.001).
This table shows molecular features associated with MIR548E in patient tissues and cancer cell lines. In patient samples, MIR548E shows the broadest associations at the RNA and protein expression levels, with COAD recurring as the lineage with the largest associated feature set.
