LRRC43

Across TCGA pan-cancer cohorts, LRRC43 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated LRRC43 data layer compared with 10 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher LRRC43 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated LRRC43 expression acts as an unfavorable survival marker, although some lineages such as HNSC and KIRP show a favorable association.

KIRC, HNSC, and SKCM are the cancer types where LRRC43 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	III,IV	0.378	0.552	.003	63	view →
HNSC	DFS	Tertile	IV	0.757	0.523	<.001	61	view →
SKCM	OS	Median	All	0.274	0.402	<.001	53	view →
KIRP	OS	Quartile	All	0.897	0.425	.002	49	view →
LUAD	OS	Median	II,III,IV	0.779	0.633	.005	37	view →
UCEC	DFS	Median	All	0.706	0.595	.008	30	view →
READ	DFS	Tertile	III,IV	0.756	0.365	<.001	30	view →
LUSC	OS	Median	II,III,IV	0.927	0.598	.001	20	view →
LGG	OS	Quartile	All	0.815	0.923	.001	18	view →
ACC	OS	Tertile	II,III,IV	1.000	0.738	<.001	17	view →
UCS	OS	Tertile	III,IV	0.682	0.217	.014	16	view →
BLCA	DFS	Quartile	IV	0.173	0.471	.007	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

LRRC43–KIRC (DFS)

Open the KIRC breakdown →