LRRC43

Across TCGA pan-cancer cohorts, LRRC43 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of LRRC43’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where LRRC43 RNA is repressed in tumor relative to normal tissue. In most cancer types LRRC43 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, KIRC, and COAD are the cancer types where LRRC43 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LRRC43 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	IV	−2.673	<.001	11	view →
KIRC	Male	II,III,IV	−1.232	<.001	11	view →
COAD	Female	All	+0.766	<.001	9	view →
BLCA	Male	All	+0.801	<.001	8	view →
LUSC	All	II,III,IV	−1.093	<.001	7	view →
THCA	Male	All	−0.475	<.001	6	view →
LUAD	Female	All	−0.847	<.001	5	view →
ESCA	All	II,III,IV	+1.075	.007	2	view →
CHOL	All	All	+0.502	.013	2	view →
PRAD	All	All	−0.426	<.001	2	view →
KIRP	All	III,IV	−0.813	.033	1	view →
HNSC	Male	III,IV	+0.305	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

LRRC43–KICH

Open the KICH breakdown →