Q-omics provides the consensus-scored LPP-AS2 profile across patient tissues and cancer cell-line models. LPP-AS2 expression is associated with patient survival in 25 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, LPP-AS2 is differentially expressed in 9, with the highest sampling consensus in THCA. Additionally, LPP-AS2 RNA expression shows 18,703 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight KIRC, THCA, and ACC as cancer lineages where LPP-AS2 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for LPP-AS2 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes LPP-AS2 survival associations across molecular data types. LPP-AS2 RNA expression shows survival associations in the most cancer types (25). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible LPP-AS2 RNA expression–survival associations across cancer types. High LPP-AS2 expression shows unfavorable associations in LGG, but favorable associations in KIRC, BRCA, LUSC, UCS and DLBC. The KIRC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for LPP-AS2 RNA expression.
This table summarizes LPP-AS2 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 9. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for LPP-AS2. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. LPP-AS2 shows lower tumor expression in THCA, COAD, KICH, BRCA and READ and higher tumor expression in LIHC. The THCA box plot shows higher LPP-AS2 RNA expression in normal versus tumor tissue (log2 FC = −1.297, t-test p < 0.001).
This table shows molecular features associated with LPP-AS2 in patient tissues and cancer cell lines. In patient samples, LPP-AS2 shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set.
