LPP-AS2

Across TCGA pan-cancer cohorts, LPP-AS2 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of LPP-AS2’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where LPP-AS2 RNA is repressed in tumor relative to normal tissue. In most cancer types LPP-AS2 is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.

THCA, COAD, and KICH are the cancer types where LPP-AS2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LPP-AS2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.297	<.001	11	view →
COAD	Female	All	−0.624	<.001	10	view →
KICH	Male	All	−1.305	<.001	8	view →
LIHC	All	All	+0.399	<.001	7	view →
BRCA	All	III,IV	−0.960	<.001	6	view →
READ	All	II,III,IV	−0.437	<.001	6	view →
LUSC	Female	All	+0.812	<.001	4	view →
KIRP	All	IV	+0.647	.006	2	view →
CHOL	Female	All	+0.646	.019	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

LPP-AS2–THCA

Open the THCA breakdown →