LPP-AS2

Across TCGA pan-cancer cohorts, LPP-AS2 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated LPP-AS2 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher LPP-AS2 RNA is associated with better overall survival. In most high-consensus cancer types, elevated LPP-AS2 expression acts as an unfavorable survival marker, although some lineages such as KIRC and BRCA show a favorable association.

KIRC, BRCA, and LGG are the cancer types where LPP-AS2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.748	0.508	<.001	57	view →
BRCA	OS	Median	III,IV	0.890	0.769	.003	55	view →
LGG	OS	Median	All	0.729	0.890	<.001	53	view →
LUSC	OS	Tertile	All	0.834	0.728	.002	44	view →
UCS	DFS	Quartile	II,III,IV	0.570	0.238	.009	30	view →
DLBC	DFS	Tertile	All	1.000	0.604	.003	20	view →
SKCM	OS	Median	All	0.394	0.233	<.001	18	view →
SARC	OS	Tertile	All	0.799	0.651	.008	13	view →
THCA	OS	Quartile	All	0.852	0.975	.016	13	view →
UCEC	DFS	Quartile	All	0.539	0.811	.011	12	view →
CHOL	OS	Tertile	All	0.754	0.351	.025	8	view →
KIRP	OS	Median	All	0.966	0.898	.011	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

LPP-AS2–KIRC (OS)

Open the KIRC breakdown →