LPCAT4

Across TCGA cell cohorts, LPCAT4 mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LPCAT4-associated genes across cancer lineages are NPAP1, DEFB134, and OR5H8. Each is linked with LPCAT4 in more than 1 cancer types. Because this analysis shows association rather than direction, both LPCAT4-to-partner and partner-to-LPCAT4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPAP1 grouped by LPCAT4-low versus LPCAT4-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LPCAT4→partner) and Y-score (partner→LPCAT4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	NPAP1 →	+0.104	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	DEFB134 →	+0.075	+4.371	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR5H8 →	+0.014	+4.662	<.001	.005	3	1
BLOOD_Lymphoma	CSTL1 →	+0.573	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	OR8B12 →	+0.139	+6.247	<.001	<.001	3	1
BLOOD_Lymphoma	TPRX1 →	+0.006	+5.209	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

NPAP1 by LPCAT4 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →