LPCAT4

Across TCGA pan-cancer cohorts, LPCAT4 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of LPCAT4’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where LPCAT4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LPCAT4 is over-expressed in tumor, although a few such as COAD and UCEC show the opposite, repressed pattern.

THCA, KIRP, and LIHC are the cancer types where LPCAT4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LPCAT4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	III,IV	+0.721	<.001	11	view →
KIRP	All	III,IV	+1.011	<.001	9	view →
LIHC	Female	II,III,IV	+0.994	<.001	9	view →
COAD	Female	All	−0.746	<.001	7	view →
LUSC	Male	II,III,IV	+0.928	<.001	6	view →
UCEC	All	All	−0.812	<.001	6	view →
BRCA	All	II,III,IV	−0.748	<.001	6	view →
KIRC	All	All	+0.346	<.001	6	view →
CHOL	Female	All	+3.750	<.001	5	view →
STAD	Male	All	+0.746	.002	5	view →
PAAD	All	All	+1.762	.006	4	view →
READ	Male	All	−1.073	.003	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

LPCAT4–THCA

Open the THCA breakdown →