LPCAT4

Across TCGA pan-cancer cohorts, LPCAT4 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated LPCAT4 data layer compared with 6 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher LPCAT4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated LPCAT4 expression acts as an unfavorable survival marker, although some lineages such as THYM and THCA show a favorable association.

KIRC, UVM, and UCS are the cancer types where LPCAT4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Quartile	All	0.489	0.706	<.001	118	view →
UVM	OS	Median	III,IV	0.378	0.905	.001	79	view →
UCS	OS	Median	II,III,IV	0.432	0.787	.002	74	view →
ACC	DFS	Median	All	0.229	0.645	<.001	71	view →
LIHC	OS	Quartile	All	0.331	0.656	<.001	59	view →
PAAD	OS	Median	All	0.274	0.505	.005	40	view →
LUAD	DFS	Median	All	0.742	0.838	.001	37	view →
THYM	DFS	Median	All	0.966	0.653	.005	29	view →
THCA	OS	Quartile	II,III,IV	1.000	0.504	.003	26	view →
SKCM	DFS	Median	All	0.249	0.153	.002	22	view →
KIRP	DFS	Tertile	IV	0.034	0.762	.010	20	view →
UCEC	DFS	Quartile	All	0.593	0.787	.002	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

LPCAT4–KIRC (OS)

Open the KIRC breakdown →