Q-omics provides the consensus-scored LNCOG profile across patient tissues and cancer cell-line models. LNCOG expression is associated with patient survival in 25 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, LNCOG is differentially expressed in 10, with the highest sampling consensus in HNSC. Additionally, LNCOG RNA expression shows 14,526 significant protein co-abundance associations, with the highest sampling consensus in BRCA. Together, these results highlight KIRC, HNSC, and BRCA as cancer lineages where LNCOG shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for LNCOG — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes LNCOG survival associations across molecular data types. LNCOG RNA expression shows survival associations in the most cancer types (25). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible LNCOG RNA expression–survival associations across cancer types. High LNCOG expression shows unfavorable associations in KIRC, STAD, LGG, CESC and LUSC, but favorable associations in THCA. The KIRC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for LNCOG RNA expression.
This table summarizes LNCOG tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 10. The strongest signals are observed in HNSC for RNA.
This table ranks reproducible tumor–normal expression differences for LNCOG. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. LNCOG shows lower tumor expression in BRCA and higher tumor expression in HNSC, THCA, COAD, LUAD and STAD. The HNSC box plot shows higher LNCOG RNA expression in tumor versus normal tissue (log2 FC = +1.846, t-test p < 0.001).
This table shows molecular features associated with LNCOG in patient tissues and cancer cell lines. In patient samples, LNCOG shows the broadest associations at the RNA and protein expression levels, with BRCA recurring as the lineage with the largest associated feature set.
