LNCOG

Across TCGA pan-cancer cohorts, LNCOG RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of LNCOG’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where LNCOG RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LNCOG is over-expressed in tumor, although a few such as BRCA and KICH show the opposite, repressed pattern.

HNSC, THCA, and COAD are the cancer types where LNCOG tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LNCOG RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+1.846	<.001	11	view →
THCA	Female	All	+0.310	<.001	10	view →
COAD	All	II,III,IV	+0.263	<.001	10	view →
LUAD	All	III,IV	+0.668	<.001	9	view →
STAD	Male	II,III,IV	+0.372	<.001	8	view →
BRCA	All	II,III,IV	−0.911	<.001	6	view →
KICH	All	All	−0.425	<.001	5	view →
PRAD	All	All	−0.135	.014	2	view →
LIHC	All	All	+0.134	.007	2	view →
CHOL	Female	All	+0.353	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

LNCOG–HNSC

Open the HNSC breakdown →