LMAN1L

Across TCGA cell cohorts, LMAN1L mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LMAN1L-associated genes across cancer lineages are IL21, CLEC4D, and PNMA6F. Each is linked with LMAN1L in more than 1 cancer types. Because this analysis shows association rather than direction, both LMAN1L-to-partner and partner-to-LMAN1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL21 grouped by LMAN1L-low versus LMAN1L-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LMAN1L→partner) and Y-score (partner→LMAN1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	IL21 →	+0.013	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	CLEC4D →	+0.006	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	PNMA6F →	+0.013	+4.643	<.001	.008	3	1
SKIN	SHOX →	+0.062	+4.930	<.001	.001	3	1
SKIN	FAM47B →	+0.017	+5.022	<.001	.002	3	1
BLOOD_Lymphoma	TRIM60 →	+0.352	+4.867	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

IL21 by LMAN1L expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →