LMAN1L

Across TCGA pan-cancer cohorts, LMAN1L RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated LMAN1L data layer compared with 4 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher LMAN1L RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated LMAN1L expression acts as an unfavorable survival marker, although some lineages such as STAD and LUAD show a favorable association.

KIRC, STAD, and READ are the cancer types where LMAN1L RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.498	0.717	.005	58	view →
STAD	OS	Median	IV	0.560	0.156	.010	57	view →
READ	DFS	Tertile	All	0.490	0.768	.012	45	view →
MESO	OS	Tertile	All	0.084	0.560	<.001	45	view →
LUAD	DFS	Tertile	All	0.745	0.633	.005	41	view →
OV	OS	Quartile	II,III,IV	0.250	0.353	.011	36	view →
UVM	OS	Tertile	III,IV	0.220	0.872	.025	27	view →
LGG	DFS	Median	All	0.310	0.450	.001	25	view →
ACC	DFS	Tertile	II,III,IV	0.420	0.816	.012	24	view →
UCEC	DFS	Median	III,IV	0.743	0.826	.028	22	view →
KICH	DFS	Quartile	All	0.586	0.906	.026	20	view →
LUSC	DFS	Quartile	III,IV	0.384	0.885	.005	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

LMAN1L–KIRC (DFS)

Open the KIRC breakdown →