long intergenic non-protein coding RNA 221Genealiases: C14orf98 · NCRNA00221
Q-omics provides the consensus-scored LINC00221 profile across patient tissues and cancer cell-line models. LINC00221 expression is associated with patient survival in 17 of 34 cancer types, with the highest sampling consensus in KIRP. Among the 18 cancer types available for tumor–normal comparison, LINC00221 is differentially expressed in 8, with the highest sampling consensus in LIHC. Additionally, LINC00221 RNA expression shows 10,084 significant gene co-expression associations, with the highest sampling consensus in TGCT. Together, these results highlight KIRP, LIHC, and TGCT as cancer lineages where LINC00221 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for LINC00221 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes LINC00221 survival associations across molecular data types. LINC00221 RNA expression shows survival associations in the most cancer types (17). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible LINC00221 RNA expression–survival associations across cancer types. High LINC00221 expression shows unfavorable associations in KIRP, UCS, CHOL, LGG and LUSC, but favorable associations in HNSC. The KIRP Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .001). Together, the overview and detailed table identify KIRP as the clearest survival context for LINC00221 RNA expression.
This table summarizes LINC00221 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 8. The strongest signals are observed in BRCA for RNA.
This table ranks reproducible tumor–normal expression differences for LINC00221. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. LINC00221 shows lower tumor expression in STAD, UCEC and KICH and higher tumor expression in LIHC, BRCA and LUSC. The LIHC box plot shows higher LINC00221 RNA expression in tumor versus normal tissue (log2 FC = +0.959, t-test p < 0.001).
This table shows molecular features associated with LINC00221 in patient tissues and cancer cell lines. In patient samples, LINC00221 shows the broadest associations at the RNA and protein expression levels, with TGCT recurring as the lineage with the largest associated feature set.
