LINC00221

Across TCGA patient cohorts, LINC00221 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,536 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible LINC00221-associated GO terms across cancer lineages are Regulation of tumor necrosis factor-mediated signaling pathway, Regulation of mitochondrial gene expression, and Translational initiation. Each is linked with LINC00221 in more than 11 cancer types. Because this analysis shows association rather than direction, both LINC00221-to-partner and partner-to-LINC00221 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of tumor necrosis factor-mediated signaling pathway grouped by LINC00221-low versus LINC00221-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LINC00221→partner) and Y-score (partner→LINC00221) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Regulation of tumor necrosis factor-mediated signaling pathway →	+0.051	+0.275	<.001	<.001	3	12
ESCA	Regulation of mitochondrial gene expression →	+0.060	+0.384	<.001	.004	3	11
STAD	Translational initiation →	+0.087	+0.388	<.001	<.001	3	11
STAD	Mitochondrial translation →	+0.089	+0.441	<.001	.001	3	11
STAD	Telomerase RNA localization →	+0.082	+0.415	<.001	<.001	3	11
ESCA	Positive regulation of cell cycle phase transition →	+0.054	+0.634	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,536 associations by consensus.

Regulation of tumor necrosis factor-mediated signaling pathway by LINC00221 expression — STAD

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