LINC00221

Across TCGA pan-cancer cohorts, LINC00221 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated LINC00221 data layer.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher LINC00221 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated LINC00221 expression acts as an unfavorable survival marker, although some lineages such as HNSC and THYM show a favorable association.

KIRP, CHOL, and UCS are the cancer types where LINC00221 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Tertile	All	0.349	0.787	.001	79	view →
CHOL	OS	Tertile	IV	0.024	0.732	.014	36	view →
UCS	DFS	Tertile	IV	0.132	0.718	.002	36	view →
LGG	DFS	Tertile	All	0.624	0.759	.005	24	view →
LUSC	DFS	Quartile	II,III,IV	0.347	0.760	<.001	20	view →
HNSC	OS	Tertile	IV	0.919	0.538	.004	15	view →
OV	OS	Quartile	III,IV	0.249	0.332	.012	14	view →
THYM	OS	Median	All	1.000	0.921	.012	10	view →
LIHC	DFS	Quartile	All	0.349	0.458	.024	9	view →
ACC	DFS	Tertile	IV	0.012	0.310	.002	9	view →
LAML	DFS	Quartile	All	0.340	0.621	.034	6	view →
STAD	DFS	Median	III,IV	0.616	0.406	.025	5	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

LINC00221–KIRP (DFS)

Open the KIRP breakdown →