LHX5 antisense RNA 1Genealiases: locus 4010 · locus4010
Q-omics provides the consensus-scored LHX5-AS1 profile across patient tissues and cancer cell-line models. LHX5-AS1 expression is associated with patient survival in 12 of 34 cancer types, with the highest sampling consensus in UCS. Among the 18 cancer types available for tumor–normal comparison, LHX5-AS1 is differentially expressed in 6, with the highest sampling consensus in HNSC. Additionally, LHX5-AS1 RNA expression shows 5,847 significant pathway-activity associations, with the highest sampling consensus in LGG. Together, these results highlight UCS, HNSC, and LGG as cancer lineages where LHX5-AS1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for LHX5-AS1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes LHX5-AS1 survival associations across molecular data types. LHX5-AS1 RNA expression shows survival associations in the most cancer types (12). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible LHX5-AS1 RNA expression–survival associations across cancer types. High LHX5-AS1 expression shows unfavorable associations in UCS, ACC, KIRP, OV and THYM, but favorable associations in LGG. The UCS Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .001). Together, the overview and detailed table identify UCS as the clearest survival context for LHX5-AS1 RNA expression.
This table summarizes LHX5-AS1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 6. The strongest signals are observed in HNSC for RNA.
This table ranks reproducible tumor–normal expression differences for LHX5-AS1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. LHX5-AS1 shows lower tumor expression in STAD, THCA and ESCA and higher tumor expression in HNSC, LUSC and KIRP. The HNSC box plot shows higher LHX5-AS1 RNA expression in tumor versus normal tissue (log2 FC = +0.143, t-test p < 0.001).
This table shows molecular features associated with LHX5-AS1 in patient tissues and cancer cell lines. In patient samples, LHX5-AS1 shows the broadest associations at the RNA and protein expression levels, with LGG recurring as the lineage with the largest associated feature set.
