LHX5-AS1

Across TCGA pan-cancer cohorts, LHX5-AS1 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of LHX5-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where LHX5-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LHX5-AS1 is over-expressed in tumor, although a few such as STAD and THCA show the opposite, repressed pattern.

HNSC, STAD, and LUSC are the cancer types where LHX5-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LHX5-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.143	<.001	8	view →
STAD	All	All	−0.450	.001	5	view →
LUSC	All	All	+0.158	<.001	3	view →
THCA	Male	All	−0.050	.006	2	view →
KIRP	All	III,IV	+0.050	.023	2	view →
ESCA	All	All	−0.643	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

LHX5-AS1–HNSC

Open the HNSC breakdown →