LHX5-AS1

Across TCGA pan-cancer cohorts, LHX5-AS1 RNA is linked to patient survival in 12 of 34 cancer types, making it the most broadly survival-associated LHX5-AS1 data layer.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher LHX5-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated LHX5-AS1 expression acts as an unfavorable survival marker, although some lineages such as LGG and LUAD show a favorable association.

UCS, ACC, and LGG are the cancer types where LHX5-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Tertile	All	0.180	0.558	.001	108	view →
ACC	DFS	Tertile	II,III,IV	0.078	0.480	<.001	105	view →
LGG	DFS	Median	All	0.816	0.659	<.001	45	view →
THYM	DFS	Tertile	All	0.091	0.884	<.001	36	view →
OV	OS	Tertile	II,III,IV	0.593	0.702	.029	36	view →
KIRP	DFS	Tertile	IV	0.088	0.502	<.001	36	view →
STAD	DFS	Tertile	II,III,IV	0.219	0.396	.009	33	view →
LUAD	DFS	Tertile	All	0.909	0.778	.006	24	view →
KICH	OS	Tertile	All	0.732	0.969	.021	18	view →
SKCM	DFS	Tertile	III,IV	0.058	0.648	.001	9	view →
BLCA	OS	Tertile	III,IV	0.735	0.619	.027	6	view →
LUSC	OS	Tertile	II,III,IV	0.815	0.704	.022	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

LHX5-AS1–UCS (DFS)

Open the UCS breakdown →