LDHA

Across TCGA patient cohorts, LDHA protein abundance is significantly associated with the RNA expression of many other genes, with 13,358 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible LDHA-associated genes across cancer lineages are EGLN3, MIR210HG, and ENO1. Each is linked with LDHA in more than 7 cancer types. Because this analysis shows association rather than direction, both LDHA-to-partner and partner-to-LDHA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LDHA versus EGLN3 in PDAC, with a Pearson correlation of 0.57.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LDHA→partner) and Y-score (partner→LDHA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	EGLN3 →	+1.487	+0.436	<.001	<.001	3	8
GBM	MIR210HG →	+1.219	+0.404	<.001	<.001	3	8
UCEC	ENO1 →	+1.112	+0.261	<.001	<.001	3	7
UCEC	PGK1 →	+1.070	+0.339	<.001	<.001	3	7
UCEC	ADM →	+1.828	+0.406	<.001	<.001	3	7
OV	PLOD2 →	+1.240	+0.381	<.001	.007	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,358 associations by consensus.

LDHA vs EGLN3 — PDAC

Explore this scatter interactively →