LDHA

Across TCGA pan-cancer cohorts, LDHA RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of LDHA’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where LDHA RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LDHA is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

KIRC, HNSC, and KIRP are the cancer types where LDHA tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LDHA RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	IV	+2.158	<.001	12	view →
HNSC	Male	II,III,IV	+1.128	<.001	12	view →
KIRP	All	II,III,IV	+1.310	<.001	10	view →
LUAD	Female	II,III,IV	+1.565	<.001	9	view →
COAD	Male	III,IV	+0.948	<.001	9	view →
STAD	All	II,III,IV	+0.797	<.001	9	view →
LUSC	Female	All	+1.587	<.001	8	view →
UCEC	All	All	+1.349	<.001	6	view →
BRCA	All	III,IV	+0.763	<.001	6	view →
BLCA	All	All	+0.641	.033	5	view →
KICH	All	All	−0.937	.002	4	view →
ESCA	All	All	+1.681	.007	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

LDHA–KIRC

Open the KIRC breakdown →