LDHA

Across TCGA pan-cancer cohorts, LDHA RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated LDHA data layer compared with 2 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher LDHA RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated LDHA expression acts as an unfavorable survival marker, although some lineages such as READ and KIRC show a favorable association.

LUAD, KIRP, and KICH are the cancer types where LDHA RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.591	0.736	<.001	132	view →
KIRP	DFS	Tertile	All	0.755	0.931	<.001	112	view →
KICH	DFS	Median	II,III,IV	0.542	0.961	<.001	104	view →
LIHC	DFS	Median	All	0.458	0.621	<.001	95	view →
HNSC	OS	Median	III,IV	0.266	0.384	.002	93	view →
ACC	DFS	Median	All	0.395	0.759	<.001	78	view →
PAAD	OS	Median	All	0.249	0.533	<.001	71	view →
CESC	OS	Quartile	All	0.447	0.727	<.001	66	view →
READ	DFS	Tertile	All	0.824	0.283	<.001	57	view →
LGG	DFS	Median	All	0.667	0.806	<.001	54	view →
KIRC	DFS	Median	All	0.688	0.558	.002	42	view →
BLCA	OS	Median	All	0.661	0.756	.013	39	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

LDHA–LUAD (DFS)

Open the LUAD breakdown →