LDHA

Across TCGA patient cohorts, LDHA mutation is significantly associated with the RNA expression of many other genes, with 937 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LDHA-associated genes across cancer lineages are MIR6780A, SEZ6L-AS1, and RBPJP6. Each is linked with LDHA in more than 1 cancer types. Because this analysis shows association rather than direction, both LDHA-to-partner and partner-to-LDHA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6780A grouped by LDHA-low versus LDHA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LDHA→partner) and Y-score (partner→LDHA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR6780A →	+0.271	+2.216	.002	.007	3	2
CESC	SEZ6L-AS1 →	+0.072	+4.969	<.001	.004	3	2
CESC	RBPJP6 →	+0.029	+6.164	<.001	<.001	3	2
UCEC	KRTAP20-3 →	+0.058	+3.890	<.001	.007	3	2
UCEC	RNU6-444P →	+0.363	+2.148	.005	.001	3	2
UCEC	TAF11L14 →	+0.258	+1.975	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 937 associations by consensus.

MIR6780A by LDHA expression — UCEC

Explore this box plot interactively →