LCE3C

Across TCGA patient cohorts, LCE3C mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible LCE3C-associated genes across cancer lineages are RNA5SP414, RPL23AP45, and PYHIN5P. Each is linked with LCE3C in more than 1 cancer types. Because this analysis shows association rather than direction, both LCE3C-to-partner and partner-to-LCE3C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP414 grouped by LCE3C-low versus LCE3C-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LCE3C→partner) and Y-score (partner→LCE3C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNA5SP414 →	+0.477	+8.471	<.001	.005	3	1
SKCM	RPL23AP45 →	+0.109	+5.682	<.001	<.001	3	1
SKCM	PYHIN5P →	+0.053	+4.771	<.001	.006	3	1
BRCA	RNA5SP422 →	+0.865	+8.055	<.001	.007	3	1
BRCA	RNA5SP416 →	+0.725	+8.471	<.001	.005	3	1
BRCA	LIMS4 →	+0.029	+9.057	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

RNA5SP414 by LCE3C expression — BRCA

Explore this box plot interactively →