Across TCGA pan-cancer cohorts, LCE3C RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of LCE3C’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where LCE3C RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LCE3C is over-expressed in tumor.
LUSC are the cancer types where LCE3C tumor–normal differential expression is most reproducible.