pyrin and HIN domain family member 5, pseudogeneGenealiases: []
Q-omics provides the consensus-scored PYHIN5P profile across patient tissues and cancer cell-line models. PYHIN5P expression is associated with patient survival in 13 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, PYHIN5P is differentially expressed in 1, with the highest sampling consensus in LUSC. Additionally, PYHIN5P RNA expression shows 5,821 significant pathway-activity associations, with the highest sampling consensus in STAD. Together, these results highlight KIRC, LUSC, and STAD as cancer lineages where PYHIN5P shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for PYHIN5P — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes PYHIN5P survival associations across molecular data types. PYHIN5P RNA expression shows survival associations in the most cancer types (13). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible PYHIN5P RNA expression–survival associations across cancer types. High PYHIN5P expression shows unfavorable associations in KIRC, CHOL, KIRP, OV, LIHC and ACC. The KIRC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for PYHIN5P RNA expression.
This table summarizes PYHIN5P tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 1. The strongest signals are observed in LUSC for RNA.
This table ranks reproducible tumor–normal expression differences for PYHIN5P. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. PYHIN5P shows higher tumor expression in LUSC. The LUSC box plot shows higher PYHIN5P RNA expression in tumor versus normal tissue (log2 FC = +0.009, t-test p = .043).
This table shows molecular features associated with PYHIN5P in patient tissues and cancer cell lines. In patient samples, PYHIN5P shows the broadest associations at the RNA and protein expression levels, with STAD recurring as the lineage with the largest associated feature set.
