Across TCGA pan-cancer cohorts, PYHIN5P RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of PYHIN5P’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where PYHIN5P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PYHIN5P is over-expressed in tumor.
LUSC are the cancer types where PYHIN5P tumor–normal differential expression is most reproducible.