LCA5L

Across TCGA patient cohorts, LCA5L mutation is significantly associated with the RNA expression of many other genes, with 2,970 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LCA5L-associated genes across cancer lineages are RN7SL248P, SNORD56B, and RPL6P29. Each is linked with LCA5L in more than 2 cancer types. Because this analysis shows association rather than direction, both LCA5L-to-partner and partner-to-LCA5L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL248P grouped by LCA5L-low versus LCA5L-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LCA5L→partner) and Y-score (partner→LCA5L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RN7SL248P →	+0.073	+4.464	<.001	.005	3	3
CESC	SNORD56B →	+0.581	+4.760	<.001	.003	3	2
SKCM	RPL6P29 →	+0.072	+3.650	<.001	<.001	3	2
BRCA	RNU6-1205P →	+0.611	+3.203	<.001	.006	3	2
BRCA	RN7SL352P →	+0.129	+3.873	.001	.003	3	2
LUAD	RPL35AP3 →	+0.354	+5.198	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,970 associations by consensus.

RN7SL248P by LCA5L expression — BRCA

Explore this box plot interactively →