LCA5L

Across TCGA pan-cancer cohorts, LCA5L RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated LCA5L data layer compared with 4 for mutation status.

The strongest signal is observed in brain lower grade glioma (LGG), where higher LCA5L RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated LCA5L expression acts as an unfavorable survival marker, although some lineages such as UCEC and BRCA show a favorable association.

LGG, CHOL, and BLCA are the cancer types where LCA5L RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	DFS	Median	All	0.655	0.815	<.001	48	view →
CHOL	DFS	Median	II,III,IV	0.115	0.630	<.001	44	view →
BLCA	OS	Median	All	0.572	0.776	.006	41	view →
KICH	OS	Tertile	All	0.725	1.000	.005	33	view →
HNSC	OS	Median	All	0.460	0.728	<.001	27	view →
KIRC	DFS	Quartile	IV	0.273	0.606	.003	24	view →
UCEC	OS	Quartile	All	0.965	0.892	.010	20	view →
BRCA	DFS	Median	III,IV	0.853	0.732	.008	18	view →
STAD	DFS	Quartile	IV	0.246	0.665	.012	18	view →
OV	DFS	Median	All	0.576	0.505	.032	16	view →
SKCM	DFS	Median	All	0.671	0.548	.003	14	view →
LIHC	DFS	Quartile	All	0.498	0.635	.020	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

LCA5L–LGG (DFS)

Open the LGG breakdown →