LCA5L

Across TCGA pan-cancer cohorts, LCA5L RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of LCA5L’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where LCA5L RNA is repressed in tumor relative to normal tissue. In most cancer types LCA5L is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and LIHC are the cancer types where LCA5L tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LCA5L RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.441	<.001	11	view →
THCA	Male	III,IV	−1.011	<.001	11	view →
LIHC	All	All	+0.165	<.001	7	view →
BRCA	All	III,IV	+0.656	<.001	6	view →
LUSC	Male	II,III,IV	−0.654	<.001	6	view →
BLCA	Female	III,IV	+0.331	.001	6	view →
COAD	Male	All	+0.296	<.001	6	view →
READ	All	III,IV	+0.520	.002	3	view →
ESCA	All	II,III,IV	+0.835	.037	2	view →
CHOL	Male	All	+0.780	<.001	2	view →
STAD	All	All	+0.188	.028	2	view →
LUAD	All	III,IV	−0.333	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

LCA5L–KICH

Open the KICH breakdown →